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Neither of these antimicrobials are innovations; both are widely spread therapeutic tools at primary health care. However, the interest for each of them is dramatically different from the pediatric point of view. On the one hand, the quinolones, overused in adults´ infectious patologies and restricted for children. On the other hand, the combination of amoxicillin with clanulanic acid, using different formulations, some of which has been almost forgotten and disdained by peditricians, is one of the most useful antibiotics in pediatrics. Old acquaintances, whose characteristics are worth updating. The selection of the right agent, along with the dose, the pattern and the duration will be essential both for an adequate treatment and to avoid bacterial resistences, and also to know their restrictions and possible adverse effects. Therefore, to deepen in the knowledge of these drugs will boost one of the elements of the fight against the increase of microbial resistances. The final goal will be to encourage the use of this antimicrobials, following the indications of guidelines and actual consensus.
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