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Vol. 20 - Num. 77

Evidence based Pediatrics

Can the diagnosis of celiac disease be based on serologic tests alone?

Manuel Molina Ariasa, Begoña Pérez-Moneo Agapitob

aServicio de Gastroenterología. Hospital Infantil Universitario La Paz. Madrid. España. Comité de Pediatría Basada en la Evidencia (AEP y AEPap). Editor de .
bHospital Universitario Infanta Leonor. Facultad de Medicina. Universidad Complutense de Madrid. Madrid. España.

Correspondence: M Molina. E-mail:

Reference of this article: Molina Arias M, Pérez-Moneo Agapito B. Can the diagnosis of celiac disease be based on serologic tests alone? Rev Pediatr Aten Primaria. 2018;20:79-82.

Published in Internet: 21-02-2018 - Visits: 6610


Authors’ conclusions: in a prospective study, we validated two procedures based on the determination of anti-glutaminase and anti-gliadin-deaminated antibodies for the identification of pediatric patients with or without celiac disease, without biopsy.

Reviewers’ commentary: although serological determinations are useful for the diagnosis of celiac disease and can allow diagnosis without duodenal biopsy, it seems reasonable to continue with the current recommendations, especially in groups of patients with low risk of disease.


Antibodies Celiac disease Endoscopy Enzyme-linked immunosorbent assay



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