Reference of this article: Castellsagué X, Bosch FX. Vaccines against human papillomavirus (HPV): incorporation of the pediatrician to the fiht against cervical cancer. Rev Pediatr Aten Primaria. 2007;9 Supl 3:S21-42.
Published in Internet: 31-12-2007 - Visits: 5718
Anogenital infection by human papillomavirus (HPV) is a very common sexually transmitted
infection in sexually active individuals. Although most infections undergo a benign course
and resolve spontaneously, persistent infection by certain HPV genotypes is causally associated
with the development of cervical cancer as well as of a fraction of other anogenital cancers.
Data from several clinical trials testing two HPV vaccines, a bivalent vaccine against HPVs
16 and 18 and a tetravalent vaccine against HPVs 6, 11, 16 and 18, indicate that both are safe,
immunogenic and highly efficacious for the prevention not only of persistent HPV infections
by the vaccine types, but also for the prevention of immediate precursor lesions of invasive cervical
cancer caused by these types. Additionally, the tetravalent vaccine has proved to be also
highly efficacious for the prevention of genital warts or condilomas and neoplasia of the vulva
and the vagina.
The biomedical and scientific community is very optimistic and believes that in the next
25-30 years a reduction in the incidence rates of cervical cancer and other HPV-related lesions
will be observed. The pediatrician plays an important role in the successful implementation of
HPV vaccines among pre-adolescent girls, the prioritized target population to achieve the maximum
preventive potential of these vaccines. The pediatrician must get involved in educating
parents and pre-adolescents about the importance of HPV vaccines for the prevention of a cancer
that may develop in adulthood. This is a unique opportunity to actively and directly contribute
to the prevention of cervical cancer.
Key words: Human papillomavirus, Vaccine, Epidemiology, Cervical cancer, Prevention.
Keywords● Cervical cancer ● Epidemiology ● Human papillomavirus ● Vaccines