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Vol. 23 - Num. 90

Childhood and Adolescence PrevInfad/PAPPS Group

Prophylaxis with vitamin K to prevent the haemorrhagic disease of the newborn

Catalina Morales Betancourta, Carmen Rosa Pallás Alonsoa, Julia Colomer Revueltab, Olga Cortés Ricoc, M.ª Jesús Esparza Olcinad, José Galbe Sánchez-Venturae, Ana Gallego Iborraf, Jaime García Aguadod, Laura García Sotog, Álvaro Rando Diegoh, José M.ª Mengual Gili

aServicio de Neonatología. Hospital Universitario 12 de Octubre. Madrid. España.
bDepartamento de Pediatría, Obstetricia y Ginecología. Unidad de Pediatría. Universidad de Valencia. Valencia. España.
cPediatra. CS Canillejas. Madrid. España.
dPediatra. Madrid. España.
ePediatra. CS Torrero La Paz. Zaragoza. España.
fPediatra. CS Trinidad. Málaga. España.
gPediatra. CS Coín. Málaga. España.
hPediatra. CS Mejorada del Campo. Velilla de San Antonio. Madrid. España.
iCoordinador del Grupo PrevInfad. Pediatra. CS Delicias Sur. Zaragoza. España.

Correspondence: J Galbe. E-mail:

Reference of this article: Morales Betancourt C, Pallás Alonso CR, Colomer Revuelta J, Cortés Rico O, Esparza Olcina MJ, Galbe Sánchez-Ventura J, et al. Prophylaxis with vitamin K to prevent the haemorrhagic disease of the newborn. Rev Pediatr Aten Primaria. 2021;23:195-205.

Published in Internet: 21-06-2021 - Visits: 4459


Vitamin K deficiency at birth is a risk factor for Haemorrhagic disease of the newborn. This bleeding prone situation can produce severe hemorrhages mainly in the skin, gastrointestinal tract and brain.

There is strong evidence that the administration of vitamin K to the newborn is safe and effective, potential side effects are mild, so there is a clear benefit of its administration.

PrevInfad workgroup recommends the prophylactic administration of 1 mg intramuscular Vitamin K to prevent the Haemorrhagic disease of the newborn.

Some special considerations for preterm newborns and for children whose parents reject intramuscular prophylaxis are explained in the document. Moreover, an operative proposal and information for parents are presented.


Haemorrhagic disease of the newborn Prevention Prophylaxis Vitamin K



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