Vol. 28 - Num. 110

Special Articles

Antimicrobial resistance: a silent threat we must confront

Cristina Rodríguez Arranza, Rafael Jiménez Alésb, Josefa Ares Álvarezc, M.ª Pilar Lupiani Castellanosd, César García Verae

aPediatra. CS La Guindalera. Logroño. La Rioja. España.
bPediatra. UGC de Puente Genil. Córdoba. España.
cPediatra. CS Virgen Peregrina. Pontevedra. España .
dPediatra. CS Camposoto. San Fernando. Cádiz. España.
ePediatra de Atención Primaria. España.

Correspondence: C Rodríguez. E-mail: crodriguez@riojasalud.es

Reference of this article: Rodríguez Arranz C, Jiménez Alés R, Ares Álvarez J, Lupiani Castellanos MP, García Vera C. Antimicrobial resistance: a silent threat we must confront . Rev Pediatr Aten Primaria. 2026;28:[en prensa].

Published in Internet: 24-06-2026 - Visits: 29

Abstract

Antimicrobial resistance (AMR) is a global public health crisis driven by the inappropriate use of antibiotics. In the EU, more than 35,000 people die each year from multidrug-resistant infections, at an estimated annual cost of €11.7 billion.

The “One Health” approach recognizes that resistance spreads across human medicine, veterinary medicine, and the environment. The EARS-Net network is the primary AMR surveillance system, monitoring key pathogens.

The European targets for 2030 include reducing total antibiotic consumption by 20% and ensuring that at least 65% falls within the AWaRe “Access” group. Spain, with a less favorable baseline situation, has been assigned one of the most demanding reduction target in the EU: 27%.

The most alarming data for primary care pediatrics are the 58.8% increase in bacteremias caused by E. coli resistant to third-generation cephalosporins (with a direct impact on the management of UTIs) and the rise in macrolide-resistant S. pneumoniae across the EU.

PRAN 2025–2027 establishes specific measures for primary care pediatrics: implementation of rapid diagnostic tests, PROA certification, promoting deferred prescribing, and updating the Spanish National Health System’s Antimicrobial Therapeutic Guidelines.

Primary care pediatrician is a key player in the fight against AMR: prioritizing “Access” antibiotics, systematizing the use of RDTs, participating in PROA teams, and provide health education are the actions with the greatest impact.

Keywords

Antibacterial agents Antimicrobial resistance Antimicrobial Stewardship Programs EARS-Net PRAN