Reference of this article: Ruiz Contreras J. Effectiveness and impact of vaccines against human papillomavirus. Rev Pediatr Aten Primaria. 2007;9 Supl 3:S77-88.
Published in Internet: 31-12-2007 - Visits: 5944
Cervical cancer is a worldwide important public health problem. The infection by human
papillomavirus (HPV) is causally related to almost every case of cervical cancer; also to a certain
amount of other cancers of the genital, anal and nasopharyngeal mucosa, and almost all
genital warts. The development of two vaccines against the infection by HPV opens the possibility
of preventing these conditions; both vaccines contain HPV serotypes 16 and 18, responsible
of, at least, 70% of cervical cancers. Besides, the tetravalent vaccine contains the HPV serotypes
6 and 11, responsible of, at least, 90% of genital warts.
Data available seem to point to a high protective effect against precancerous lesions in
young women in studies after five years of follow up; the tetravalent vaccine also gives effective protection against genital warts. Nevertheless, there still remain many aspects to be explained
related to the real effectiveness and cost-benefit of these vaccines.
Key words: Uterine cervix cancer, Human papillomavirus, Vaccines, Systematic vaccines,
Keywords● Cervical cancer ● Human papillomavirus ● Systematic immunization ● Vaccines