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Vol. 26 - Num. 102

Clinical Reviews in Digestive Diseases

Attention, attention: big liver and large spleen!

Noelia Carrillo Péreza, Concepción de Alba Romerob, Iván Carabaño Aguadoa

aSección de Gastroenterología, Hepatología y Nutrición Pediátrica. Servicio de Pediatría. Hospital Universitario 12 de Octubre. Madrid. España.
bServicio de Neonatología. Hospital Universitario 12 de Octubre. Madrid. España.

Correspondence: N Carrillo. E-mail: cnoelia4@gmail.com

Reference of this article: Carrillo Pérez N, de Alba Romero C, Carabaño Aguado I. Attention, attention: big liver and large spleen! . Rev Pediatr Aten Primaria. 2024;26:189-91. https://doi.org/10.60147/65f4086d

Published in Internet: 21-06-2024 - Visits: 455

Abstract

Transient myeloproliferative syndrome (TMPS) is a hematological abnormality characteristic of patients with Down syndrome. It appears in the neonatal period. It is characterized by a large leukocytosis in peripheral blood, at the expense of leukocytes of abnormal morphology (blasts). Patients are usually asymptomatic. In a small percentage, TMPS can manifest as severe symptoms derived from the infiltration of these cells into different organs, liver included. Hepatosplenomegaly, in fact, is a very useful guiding sign to start the diagnostic process.

Keywords

Down syndrome Hepatomegaly Splenomegaly Transient myeloproliferative syndrome

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