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Vol. 24 - Num. 95

Clinical Reviews in Digestive Diseases

Jaundice in infants: beyond biliary atresia

Irene Gómez-Pastrana Paua, Itziar Bueno Vidána, Enrique Medina Beníteza, Sonia Mayo de Andrésb, Enrique Salcedo Lobatoa, Iván Carabaño Aguadoa

aSección de Gastroenterología, Hepatología y Nutrición Pediátrica. Servicio de Pediatría. Hospital Universitario 12 de Octubre. Madrid. España.
bServicio de Genética Clínica. Hospital Universitario 12 de Octubre. Madrid. España.

Reference of this article: Gómez-Pastrana Pau I, Bueno Vidán I, Medina Benítez E, Mayo de Andrés S, Salcedo Lobato E, Carabaño Aguado I. Jaundice in infants: beyond biliary atresia . Rev Pediatr Aten Primaria. 2022;24:311-5.

Published in Internet: 04-10-2022 - Visits: 5002


Cholestasis is a condition defined by elevated direct bilirubin serum levels (>2 mg/dl or >20% of total bilirubin) and is usually accompanied by jaundice, dark urine, and acholia. Many diseases that cause this condition, but in the case of neonatal cholestasis, it is essential to rule out extrahepatic bile duct atresia (EBVA) on an urgent basis, since it requires early surgical intervention to divert bile flow due to its impact on future outcomes. In the presence of neonatal cholestasis in which EBVA has been ruled out, the differential diagnosis is based on the evaluation of different factors, such as gamma-glutamyl transferase (GGT) and bile acid levels, the suspicion of metabolic disease or the presence of other associated abnormalities.


Bile duct atresia Cholestasis Jaundice


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