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Vol. 22 - Num. 85

Evidence based Pediatrics

Proton pump inhibitors and increased fracture hazard. Another reason for an appropriate prescription of these drugs

Manuel Molina Ariasa, Begoña Pérez-Moneo Agapitob

aServicio de Gastroenterología. Hospital Infantil Universitario La Paz. Madrid. España.
bHospital Universitario Infanta Leonor. Universidad Complutense de Madrid. Madrid. España.

Correspondence: M Molina. E-mail: mma1961@gmail.com

Reference of this article: Molina Arias M, Pérez-Moneo Agapito B. Proton pump inhibitors and increased fracture hazard. Another reason for an appropriate prescription of these drugs. Rev Pediatr Aten Primaria. 2020;22:81-4.

Published in Internet: 10-03-2020 - Visits: 1543

Abstract

Authors’ conclusions: infant proton pump inhibitors alone or together with H2 receptor antagonists is associated with an increased childhood fracture risk. This risk appears amplified by duration or early initiation of the therapy.

Reviewers’ commentary: the increased risk of fractures associated with antisecretory treatment during the first year of life another argument to carefully assess the indication of these drugs, especially proton pump inhibitors, particularly in treatments at an early age or long-term treatments.

Keywords

Bone fractures Children Histamine H₂ antagonists Infants Proton pump inhibitors

 

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