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Vol. 21 - Num. 81

Clinical Reviews

Rare thyroid hormone profile. Thyroid hormone resistance syndrome

Mercedes Marbán Calzóna, Alicia González Jimenoa, Alba García Bermejob, Zaira Belmonte Pintrec

aServicio de Endocrinología Pediátrica. Hospital General La Mancha Centro. Alcázar de San Juan. Ciudad Real. España.
bServicio de Pediatría. Hospital Universitario Infanta Elena. Valdemoro. Madrid. España.
cServicio de Pediatría. Hospital General La Mancha Centro. Alcázar de San Juan. Ciudad Real. España.

Correspondence: M Marbán. E-mail: mmarbanc@gmail.com

Reference of this article: Marbán Calzón M, González Jimeno A, García Bermejo A, Belmonte Pintre Z. Rare thyroid hormone profile. Thyroid hormone resistance syndrome. Rev Pediatr Aten Primaria. 2019;21:e1-e5.

Published in Internet: 16-01-2019

Abstract

It can only be ensured that thyroid function is normal when thyroid-stimulating hormone and free thyroid hormones thyroxine and triiodothyronine levels are normal. A hormonal pattern with elevated free thyroxine and triiodothyronine and unsuppressed thyroid-stimulating hormone is very rare, and its main cause is thyroid hormone resistance syndro¬me, a rare genetic entity that can associate symptoms of hypo and hyperthyroidism and whose diag¬nosis requires a high rate of suspicion. In children, the sole or main manifestation may be an attention deficit hyperactivity disorder. We present a family characterized by the initial diagnosis of twin sisters at 20 months of age.

Keywords

Free thyroid hormones Thyroid hormone resistance

 

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