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Vol. 19 - Num. 73

Critical appraisal in small doses

Sequential designs: early interruption of clinical trial

Manuel Molina Ariasa

aServicio de Gastroenterología Pediátrica. Hospital Universitario La Paz. Madrid. España.

Correspondence: M Molina. E-mail: mma1961@gmail.com

Reference of this article: Molina Arias M. Sequential designs: early interruption of clinical trial. Rev Pediatr Aten Primaria. 2017;19:87-90.

Published in Internet: 04-01-2017

Abstract

Unlike in the usual parallel clinical trials, in sequential designs the sample size is not fixed, but depends on the results of interim analysis that will be carried out throughout the study. The results of these interim analyzes will determine if the trial can be interrupted or must continue until reaching a previously set maximum sample size.

Keywords

Interim analysis Sequential trials

 

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