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Vol. 18 - Num. 71

Critical appraisal in small doses

Network meta-analysis

Manuel Molina Ariasa

aServicio de Gastroenterología Pediátrica. Hospital Universitario La Paz. Madrid. España.

Correspondence: M Molina. E-mail:

Published in Internet: 29-08-2016


Meta-analysis are studies aimed to synthesize all the available information about a specific topic to get a summary measure of outcome. When there are more than two possible comparisons, traditional meta-analysis does not allow stablishing all the possible comparisons if there are not studies with the specific paired comparisons. For these circumstances, network meta-analysis have been designed which can performed multiple direct and indirect comparisons from a network of studies that examines the effects of various treatments more fully.


Direct comparisons Indirect comparisons Network meta-analysis Systematic review



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