Prolonged jaundice due to transient congenital hypothyroidism and negative neonatal screening test

Congenital hypothyroidism is a clinical entity that requires prompt diagnosis and treatment. In spite of neonatal screening for congenital hypothyroidism, there are still cases that are diagnosed after the neonatal period. The case presented below is an infant with transient congenital hypothyroidism detected in the second month of life by prolonged jaundice. The objective of this article is to remember that in the presence of symptoms like prolonged jaundice, it is necessary to discard a congenital hypothyroidism even though the screening test at birth was normal.