Cancer. General environment. Basic aspects of epydemiology, aetiology, genetics and diagnosis
Áurea Cervera Bravoa
aServicio de Pediatría. Hospital Universitario de Móstoles. Móstoles. Madrid. España.
Reference of this article: Cervera Bravo A. Cancer. General environment. Basic aspects of epydemiology, aetiology, genetics and diagnosis. Rev Pediatr Aten Primaria. 2005;7:423-439.
Published in Internet: 30-09-2005
Childhood cancer is rare, comprising less than 1% of all malignancies diagnosed each
year, but it is the disease that originates more deaths in children 0-14 years of age, with an
annual incidence of 140/1,000,000 children. Actual survival has surpassed 75%. The principal
advances in cancer research have taken place in Genetics and Molecular Biology, in
the knowledge of the molecular mechanisms that originate cancer at the cellular level. This
has contributed to a better diagnosis and treatment. The epidemiological bases of the different
types of childhood cancer, its etiology both in its genetic and environmental aspects
and the familial hereditary cancer predisposing syndromes are discussed. Finally, practical
clues about childhood cancer diagnosis in paediatric primary care are commented.
Keywords● Cancer ● Carcinogenesis ● Environmental health ● Epidemiology ● Etiology