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Vol. 24 - Num. 95

Original Papers

Sensitivity of the Panbio COVID-19 rapid antigen detection test in primary care

Ana M.ª Alonso Rubioa, Mercedes Garrido Redondob, M.ª Rosario Bachiller Luquec, M.ª Luisa Vega Gutiérrezc, Cristina García de Riverad, Beatriz Liras Muñoze, Teresa Palencia Ercillaf, Mónica Sanz Fernándezg, María Alonso Ballesterosh, Mari Fe Muñoz Morenoi, Paula Borregón Garridoj

aPediatra. CS Covaresa-Parque Alameda. Valladolid. España.
bPediatra. CS La Tórtola. Valladolid. España.
cPediatra. CS Pilarica. Valladolid. España.
dPediatra. CS Rondilla. Valladolid. España.
ePediatra. CS Cuéllar. Cuellar. Segovia. España.
fPediatra. CS Cuellar. Cuellar. Segovia. España.
gPediatra. CS Pisuerga. Arroyo de la Encomienda. Valladolid. España.
hPediatra. CS Medina del Campo. Valladolid. España.
iPediatra. Unidad de Apoyo a la Investigación. Hospital Clínico Universitario. Valladolid. España.
jEstudiante de Medicina. Facultad de Medicina. Universidad de Valladolid. Valladollid. España.

Correspondence: AM Alonso . E-mail: alonsoam04@hotmail.com

Reference of this article: Alonso Rubio AM, Garrido Redondo M, Bachiller Luque MR, Vega Gutiérrez ML, García de Rivera C, Liras Muñoz B, et al. Sensitivity of the Panbio COVID-19 rapid antigen detection test in primary care . Rev Pediatr Aten Primaria. 2022;24:e283-e289.

Published in Internet: 21-09-2022 - Visits: 1082

Abstract

Introduction and objectives: primary care paediatricians need reliable rapid diagnostic techniques (RDTs) to prevent the spread of coronavirus disease 19 (COVID-19) through early and effective screening while awaiting a vaccine. The objective of this study was to evaluate the sensitivity (Sen) of the Abbott laboratory SARS-CoV-2 Panbio antigen test, newly introduced in primary care, in both adults and children (symptomatic and asymptomatic contacts) in comparison to the polymerase chain reaction (PCR) test.

Sample and methods: the study included 591 patients (222 aged less than 14 years) from 7 primary care centres; of who 249 were symptomatic and 342 asymptomatic contacts. We calculated the Sen and specificity (Spe) with their 95% confidence intervals (CIs). We assessed the independence of the two results with the McNemar test.

Results: the Sen of the test within 5 days from onset was 81% in adults (95% CI, 66.16-96.34) and 80% in children (95% CI: 34.94-100). In contacts, we assessed the Sen within 5 days, in adults (68%; 95% CI: 51.13- 86.37), in 5 to 9 days (85%) and in children (66%; 95% CI: 30.31-100). The most frequent source of exposure were household contacts (52% of the cases). The Spe was 100% in every case.

Conclusions: the Panbio SARS-CoV-2 rapid antigen test can be useful for diagnosis in adults and children within 5 days of onset, and from days 5 to 9 in contacts of confirmed COVID 19 cases. Further studies are required for adequate interpretation of the latter result.

Keywords

COVID-19 Point-of-care diagnostics Primary care SARS-CoV-2

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