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Vol. 23 - Num. 92

Evidence based Pediatrics

Metformin could be of help in the treatment of obesity

M.ª Jesús Esparza Olcinaa, M.ª Mercedes Fernández Rodríguezb

aPediatra de Atención Primaria. Madrid. España.
bPediatra. CS Potes. Madrid. España.

Correspondence: MJ Esparza. E-mail:

Reference of this article: Esparza Olcina MJ, Fernández Rodríguez MM. Metformin could be of help in the treatment of obesity. Rev Pediatr Aten Primaria. 2021;23:429-32.

Published in Internet: 07-12-2021 - Visits: 428


Authors’ conclusions: metformin associated with lifestyle interventions may have a small favorable effect on BMI z-score and insulin resistance. It shows an acceptable safety profile in children and adolescents with obesity. The quality of the available evidence is variable.

Reviewers’ commentary: obesity drug therapy could help to achieve targets in the short and medium term, but the effect in the long term remains unknown. Metformin has a modest effect on BMI and produces frequent gastrointestinal adverse events that could reduce completion of treatments. Individual use of metformin could be proposed in specific obesity cases, especially if they present metabolic consequences.


Insulin resistance Metformin Pediatric obesity



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