Rare thyroid hormone profile. Thyroid hormone resistance syndrome
Mercedes Marbán Calzóna, Alicia González Jimenob, Alba García Bermejoc, Zaira Belmonte Pintred
aServicio de Endocrinología Pediátrica. Hospital General La Mancha Centro. Alcázar de San Juan. Ciudad Real. España.
bServicio de Pediatría. Hospital General La Mancha Centro. Alcázar de San Juan. Ciudad Real. España.
cServicio de Pediatría. Hospital Universitario Infanta Elena. Valdemoro. Madrid. España.
dMIR-Pediatría. Complejo Hospitalario La Mancha Centro. Alcázar de San Juan. Ciudad Real. España.
Correspondence: M Marbán. E-mail: mmarbanc@gmail.com
Reference of this article: Marbán Calzón M, González Jimeno A, García Bermejo A, Belmonte Pintre Z. Rare thyroid hormone profile. Thyroid hormone resistance syndrome. Rev Pediatr Aten Primaria. 2019;21:e1-e5.
Published in Internet: 16-01-2019 - Visits: 22087
Abstract
It can only be ensured that thyroid function is normal when thyroid-stimulating hormone and free thyroid hormones thyroxine and triiodothyronine levels are normal. A hormonal pattern with elevated free thyroxine and triiodothyronine and unsuppressed thyroid-stimulating hormone is very rare, and its main cause is thyroid hormone resistance syndro¬me, a rare genetic entity that can associate symptoms of hypo and hyperthyroidism and whose diag¬nosis requires a high rate of suspicion. In children, the sole or main manifestation may be an attention deficit hyperactivity disorder. We present a family characterized by the initial diagnosis of twin sisters at 20 months of age.
Keywords
● Free thyroid hormones ● Thyroid hormone resistance
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