Spontaneous periodic hypothermia and hyperhidrosis: a case report and a literature review

Spontaneous periodic hypothermia is a disorder characterized by repeated episodes of hypothermia and sweating in the absence of neurological, endocrine, metabolic injury or intercurrent infections. Bradycardia, pale skin and general malaise feeling can also be associated to this condition. Its prevalence is unknown. It can be diagnosed when other causes have been excluded. Due to the lack of published cases, its pathogenic mechanism is yet unknown. Several hypotheses, such as epilepsy, migraine equivalent or alterations of neurotransmitters, have been described. Therefore, there is not a specific treatment. Our objective is to present a case and to review the literature.