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Vol. 18 - Num. 70

Critical appraisal in small doses

Re-randomization: in search of the simple size

Manuel Molina Ariasa

aServicio de Gastroenterología. Hospital Infantil Universitario La Paz. Madrid. España.

Correspondence: M Molina. E-mail: mma1961@gmail.com

Reference of this article: Molina Arias M. Re-randomization: in search of the simple size. Rev Pediatr Aten Primaria. 2016;70:185-8.

Published in Internet: 13-06-2016 - Visits: 4321


There are some situations or conditions in which patients require treatment on multiple occasions. The most common in clinical trials is to randomize patients once in each trial. However, the sample can be increased if recruitment allows each patient to be randomized each time requiring treatment and not only once at the beginning of the trial. This is the procedure known as re-aleatorización.


Clinical Trials Re-randomization Sample size



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