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Vol. 17 - Num. 68

Critical appraisal in small doses

Case-crossover studies

Manuel Molina Ariasa

aServicio de Gastroenterología. Hospital Infantil Universitario La Paz. Madrid. España.

Correspondence: M Molina. E-mail:

Reference of this article: Molina Arias M. Case-crossover studies. Rev Pediatr Aten Primaria. 2015;17:373-6.

Published in Internet: 23-11-2015 - Visits: 7041


The case-crossover studies or self-monitoring cases answer the question of wether there has been any unusual event that has been promoting the emergence of the event or disease under study. In this type of study, each subject serves as his or her own control, comparing case times with control times within each individual. This achieves to avoid bias selection of controls and to maintain balanced confounding variables that may exist, so that they remain stable throughout the study.


Cross-case study Hybrid designs Self-monitoring case studies



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