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Vol. 16 - Num. 62

Evidence based Pediatrics

What’s the clinical impact of using probiotics for infant colic?

E Llerena Santa Cruza, Sophie Jullienb

aServicio de Pediatría. Hospital Universitario Doctor Josep Trueta. Girona. España.
bISGlobal. Universitat de Barcelona. Barcelona. España. Ministry of Health. Timbu. Bután.

Reference of this article: Llerena Santa Cruz E, Jullien S. What’s the clinical impact of using probiotics for infant colic? Rev Pediatr Aten Primaria. 2014;16:155-8.

Published in Internet: 17-06-2014 - Visits: 14903


Authors’ conclusions: although L. reuteri may be effective as a treatment strategy for crying in exclusively breastfed infants with colic, the evidence supporting probiotics use for the treatment of infant colic or crying in formula-fed infants remains unresolved. Results from larger rigorously designed studies will help draw more definitive conclusions.

Reviewers’ commentary: L. reuteri is useful in reducing the time of infant crying, reduces it an average of 55 minutes per day, but only in mothers under exclusive breastfeeding and cow milk protein-free diet. It is still premature to generalize these results, and it is not known if this strain will work in different populations or if it is cost-effective to give this treatment for 21 days.


Infantile colic Lactobacillus reuteri Probiotics Systematic review



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