Vol. 14 - Num. 54
Evidence based Pediatrics
aPediatra. CS Cáceres-Mejostilla. Área Sanitaria de Cáceres. Cáceres. España.
bPediatra. CS Olaguibel. Servicio Vasco de Salud-Osakidetza. Vitoria-Gasteiz. Álava. España.
Correspondence: D Barroso. E-mail: email@example.com
Reference of this article: Barroso Espadero D, Ugarte Libano R. How can melatonin be useful to school age children and adolescents with sleep onset delay? Rev Pediatr Aten Primaria. 2012;14:167-77.
Published in Internet: 09-07-2012 - Visits: 13861
Authors’ conclusions: melatonin demonstrated efficacy (sleep parameters) in school aged children and adolescents whit delayed sleep phase disorders: advancing sleep onset time, delayed latency, and others. An earlier time of administration could increase the effect. The adverse events rates were: low (none serious). Results in waking hours (cognition, general health, mood…): few improvements.
Reviewers' commentary: the results evidenced that melatonin did better than placebo. It could be used in selected cases of chronic sleep onset insomnia. Small benefit (doubtful clinical significance) that disappears after short-term treatment periods. Remain unproved: prolonged treatments (safety…); benefits in waking hours; recommendation of earlier time of administration. Patients with longer times of delay: not specifically investigated.
Evidences coming from few studies of small sample size, most of them not from healthy children (high percentages of: ADHD, comorbidities and stimulants drugs).
Keywords● Adolescent ● Child ● Melatonin ● Sleep disorders ● Sleep disorders, circadian rhythm ● Treatment
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