Eyelid edema as an oligosymptomatic expression of infectious mononucleosis

Infectious mononucleosis is a common disease in children, whose incidence is highest in early childhood and adolescence or early adulthood. Bilateral eyelid edema may be a subtle clinical finding in the course of that entity, and although not part of the characteristic symptoms may be present at the onset of up to one third of patients. We present four cases in which bilateral eyelid edema is a symptom guide for the diagnosis, thus reflecting the need to include infectious mononucleosis in the differential diagnosis raised against the palpebral edema.