Benign transient hyperphosphatasemia of infancy: a condition to be considered

María del Rosario García Luzardo^a, N Rodríguez Calcines^a, E Colino Gil^b

^aServicio de Urgencias Pediátricas. Hospital Universitario Materno-Infantil de Canarias. Las Palmas de Gran Canarias. España.
^bHospital Universitario Materno-Infantil de Canarias. Las Palmas de Gran Canarias. Gran Canarias. España.

Correspondence: MR García. E-mail: saragarlu@telefonica.net

Reference of this article: García Luzardo MR, Rodríguez Calcines N, Colino Gil E. Benign transient hyperphosphatasemia of infancy: a condition to be considered. Rev Pediatr Aten Primaria. 2011;13:107-11.

Published in Internet: 06-04-2011 - Visits: 36195

Abstract

Benign transient hyperphosphatasemia of infancy (BTHI) is a condition where disproportionately high levels of serum alkaline phosphatase are observed, without clinical or biochemical evidence of bone, liver, renal or metabolic disease.

We report a case of an eight months old patient presenting with fever and important increase of serum alkaline phosphatase.

The HTBI is a frequent entity to be considered in order to avoid unnecessary investigations. If a patient has high alkaline phosphatase level, with physical examination, calcium, phosphate and liver normal profile, he/her should be monitored clinically and by measuring alkaline phosphatase levels until normalization. If high level persists after 3 months, the origin of the isoenzymes and a family study should be investigated.

Keywords

● Alkaline phosphatase ● Hyperphosphatasemia

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