Combined or alternating therapy is more effective against fever, but is this the real issue?

Authors’ conclusions: dual therapy may be superior to single therapy in the treatment of fever in keeping children afebrile at 4 and 6 hours. High-dose ibuprofen was also slightly superior to acetaminophen at 4 hours, but not at 6 hours.

Reviewers’ commentary: alternating and, especially, combination treatment can promote the notion that fever must be suppressed, when the actual goal of treatment should be to manage discomfort. They can also be a source of administration errors. For these reasons, combination or alternating antipyretic treatment, though probably more effective, is unnecessary, as there is no evidence of its clinical usefulness.